Instance ID11636
Regular ExpressionL[EQ]E[FL]LG[DE]
Motif InstanceLQELLGE
Bait Uniprot AccessionQ05086
Bait Uniprot IdentifierUBE3A_HUMAN
Bait Gene NameUBE3A
Bait OrganismHomo sapiens (Human)
Sequence Position409-415
Critical ResiduesP1; P4; P5
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)NMR; Mutational analysis; Pull down(GST tag)
Interaction ID21636
Interacting DomainUnknown
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)8393140, 9472622, 11170455
CommentsConsensus E6-binding sequence in E6AP ubiquitin-protein ligase (UBE3A) for binding to E6 oncoprotein of Human papillomavirus type 16

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)