Instance ID11653
Regular ExpressionPPxY
Motif InstancePPPY
Bait Uniprot AccessionQ01196
Bait Uniprot IdentifierRUNX1_HUMAN
Bait Gene NameRUNX1
Bait OrganismHomo sapiens (Human)
Sequence Position355-358
Critical ResiduesP1; P2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Pull down(GST tag)
Interaction ID21653
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10228168
CommentsThe PY motif (PPxY) in the subregion of the transcription activation domain of the DNA-binding subunit of human Runt-related transcription factor 1 (or PEBP2alpha) that mediates binding to the WW domain of human Yes-associated protein (YAP)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)