Instance ID11667
Regular ExpressionD[ST]xL$
Motif InstanceDSLL
Bait Uniprot AccessionP07550
Bait Uniprot IdentifierADRB2_HUMAN
Bait Gene NameADRB2
Bait OrganismHomo sapiens (Human)
Sequence Position410-413
Critical ResiduesP1; P2; P4
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutational analysis; Ligand Overlay Assay
Interaction ID21667
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9560162, 9671706
CommentsC-terminal PDZ domain-binding motif in human Beta-2 adrenergic receptor that mediates binding to the first PDZ domain of the Na+/H+ exchanger regulatory factor (NHERF) and may play a role in beta2-adrenergic receptor-mediated regulation of Na+/H+ exchange

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)