Instance ID11677
Regular ExpressionYYKSLRR
Motif InstanceYYKSLRR
Bait Uniprot AccessionQ92496
Bait Uniprot IdentifierFHR4_HUMAN
Bait Gene NameCFHR4
Bait OrganismHomo sapiens (Human)
Sequence Position35-41
Critical ResiduesP1; P2; P3; P6; P7
Motif PTM(s)Unknown
Secondary StructureHypervariable loop
Experimental Method(s)Mutational analysis; Microtiter plate binding assay; Peptide array; Competition binding assay
Interaction ID21677
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)20042240, 19084272
CommentsC-reactive protein (CRP) binding motif found at the solvent-exposed hypervariable loop located between two beta-strands (denoted b2 and b3) of the first short consensus repeat (SCR1) domain surface of human complement factor H-related protein 4 (CFHR4)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)