Instance ID11723
Regular ExpressionPxxPxR
Motif InstancePPVPPR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Bait OrganismHomo sapiens (Human)
Sequence Position1151-1156
Critical ResiduesP1; P4; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Peptide binding assay; SPR; ITC
Interaction ID21723
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)18778683, 8493579, 9383403, 7629138
CommentsThe SH3 domain-binding PxxPxR motif 2 (1151-1156) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)