Instance ID11725
Regular ExpressionPxxPxR
Motif InstancePLLPPR
Bait Uniprot AccessionQ07889
Bait Uniprot IdentifierSOS1_HUMAN
Bait Gene NameSOS1
Bait OrganismHomo sapiens (Human)
Sequence Position1212-1217
Critical ResiduesP1; P4; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Peptide binding assay
Interaction ID21725
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8493579, 9383403, 7629138
CommentsThe SH3 domain-binding PxxPxR motif 4 (1212-1217) in human hSos1 protein that binds to the SH3 domains of human adapter protein GRB2 for the transduction of signals from receptor tyrosine kinases to Ras

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)