Instance ID11737
Regular ExpressionPxxPxR
Motif InstancePPKPSR
Bait Uniprot AccessionP34152
Bait Uniprot IdentifierFAK1_MOUSE
Bait Gene NamePtk2
Bait OrganismMus musculus (Mouse)
Sequence Position750-755
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis; Y2H
Interaction ID21737
Interacting DomainSH3 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)7479864
CommentsThe SH3 domain-binding PxxPxR motif (750-755) in mouse Focal adhesion kinase 1 that binds the SH3 domain of a v-Crk-associated tyrosine kinase substrate, p130Cas (Breast cancer anti-estrogen resistance protein 1 or Bcar1). This motif, and its interaction it mediates, may be important in the invasion of host cells by Salmonella typhimurium

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)