Instance ID11753
Regular ExpressionxPxxP
Motif InstanceRPQVP
Bait Uniprot AccessionP03407
Bait Uniprot IdentifierNEF_HV1A2
Bait Gene Namenef
Bait OrganismHuman immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)
Sequence Position75-79
Critical ResiduesP2; P5
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)Mutational analysis
Interaction ID21753
Interacting DomainSH3 domain
Disease Association(s)HIV-1 pathogenicity
Inhibitor(s)Unknown
Reference(s)7588629
CommentsThe SH3 domain-binding proline-rich (xPxxP) motif in HIV-1 Nef protein that is necessary for its interaction with human Hck SH3, leading to aberrant activation of HCK, which enhances HIV-1 replication and contributes to HIV-1 pathogenicity

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)