Instance ID11755
Regular Expression[RK]xxPxxP
Motif InstanceRTPPKSP
Bait Uniprot AccessionP11137
Bait Uniprot IdentifierMTAP2_HUMAN
Bait Gene NameMAP2
Bait OrganismHomo sapiens (Human)
Sequence Position1648-1654
Critical ResiduesUnknown
Motif PTM(s)Phosphorylation at Thr-P2 & Ser-P6
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; ELISA
Interaction ID21755
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11546790
CommentsThe SH3 domain-binding motif in human Microtubule-associated protein 2 [isoform MAP-2c (residues 292-298)] that binds the SH3 domain of human proto-oncogene c-Fyn [Phosphorylation of MAP-2c at this motif by ERK2 abolishes its interaction with Fyn]

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)