Instance ID11770
Regular ExpressionPxPxPR
Motif InstancePKPRPR
Bait Uniprot AccessionQ13191
Bait Uniprot IdentifierCBLB_HUMAN
Bait Gene NameCBLB
Bait OrganismHomo sapiens (Human)
Sequence Position906-911
Critical ResiduesP1; P5; P6
Motif PTM(s)Unknown
Secondary StructurePPII helix
Experimental Method(s)X-ray crystallography; Site-directed mutagenesis; ITC; Peptide binding assay; Competition binding assay
Interaction ID21770
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12874286, 16228008
CommentsA novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL-B specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)