Instance ID11773
Regular ExpressionPxPxPR
Motif InstancePKPFPR
Bait Uniprot AccessionP22681
Bait Uniprot IdentifierCBL_HUMAN
Bait Gene NameCBL
Bait OrganismHomo sapiens (Human)
Sequence Position824-829
Critical ResiduesP6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis; ITC; Peptide binding assay; Competition binding assay
Interaction ID21773
Interacting DomainSH3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12874286, 16228008
CommentsA novel polyproline-arginine motif (PXXXPR) in human E3 ubiquitin-protein ligase CBL specifically recognized by the SH3 domains of SH3 domain-containing kinase-binding protein 1 (CIN85)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)