Instance ID11786
Regular Expression[AET]xYLxxLN
Motif InstanceARYLQKLN
Bait Uniprot AccessionQ19KW5
Bait Uniprot IdentifierQ19KW5_STREQ
Bait Gene Nameemm
Bait OrganismStreptococcus dysgalactiae subsp. equisimilis (Streptococcus equisimilis)
Sequence Position81-88
Critical ResiduesP1; P3; P4; P7
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis; SPR; Peptide binding assay
Interaction ID21786
Interacting DomainCB3 region
Disease Association(s)Rheumatic fever
Inhibitor(s)Unknown
Reference(s)17452321, 19520603
CommentsThe octapeptide collagen-binding motif known as “Peptide Associated with Rheumatic Fever” (PARF) in the M protein of Streptococcus dysgalactiae subsp. equisimilis that helps to bind the CB3-region of human Collagen alpha-4(IV) chain

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)