Instance ID11797
Regular Expression[DE][LI]xCxE
Motif InstanceDLFCSE
Bait Uniprot AccessionQ2I7F9
Bait Uniprot IdentifierQ2I7F9_SV40
Bait Gene Namelarge T
Bait OrganismSimian virus 40 (SV40)
Sequence Position101-106
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)X-ray crystallography; Competition binding assay
Interaction ID21797
Interacting DomainB-box portion of the Rb pocket domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)2138977, 2198278, 11226179
CommentsThe LxCxE motif of SV40 large T antigen that binds to the B-box portion of the pocket domain of the human retinoblastoma suppressor protein (pRb) and is required for inactivation of pRb that leads to tumorigenesis induced by SV40

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)