Instance ID11798
Regular Expression[DE][LI]xCxE
Motif InstanceDLTCHE
Bait Uniprot AccessionP03255
Bait Uniprot IdentifierE1A_ADE05
Bait Gene NameNot Available
Bait OrganismHuman adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)
Sequence Position121-126
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; Competition binding assay
Interaction ID21798
Interacting DomainB-box portion of the Rb pocket domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)2138977, 2198278
CommentsThe LxCxE motif of adenovirus E1A protein that binds to the human retinoblastoma suppressor protein (pRb) and is required for transformation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)