Instance ID11799
Regular Expression[DE][LI]xCxE
Motif InstanceDLYCYE
Bait Uniprot AccessionP03129
Bait Uniprot IdentifierVE7_HPV16
Bait Gene NameE7
Bait OrganismHuman papillomavirus type 16
Sequence Position21-26
Critical ResiduesP1; P3; P4; P5; P6
Motif PTM(s)Unknown
Secondary StructureExtended conformation
Experimental Method(s)X-ray crystallography; Mutational analysis; ITC; Competition binding assay
Interaction ID21799
Interacting DomainB-box portion of the Rb pocket domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)2198278, 9495340
CommentsThe LxCxE motif of the human papilloma virus type-16 E7 protein (HPV-16 E7) that binds a highly conserved groove on the B-box portion of the pocket domain of the human retinoblastoma suppressor protein (pRb) and is believed to be important in the process of cellular transformation that leads to cervical carcinoma

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)