Instance ID11819
Regular ExpressionQ[VI]CF
Motif InstanceQVCF
Bait Uniprot AccessionP04608
Bait Uniprot IdentifierTAT_HV1H2
Bait Gene Nametat
Bait OrganismHuman immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Sequence Position35-38
Critical ResiduesP2; P4
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis
Interaction ID21819
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16131488
CommentsConserved Q[VI]CF sequence of Transactivating regulatory protein Tat found in among different HIV-1 isolates that participates in binding to human protein phosphatase PP1. Tat might function as a nuclear regulator of PP1 and interaction of Tat with PP1 is critical for activation of HIV-1 transcription by Tat

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)