Instance ID11856
Regular Expression[ND]xY[ST]xxP
Motif InstanceDGYTPEP
Bait Uniprot AccessionP43403
Bait Uniprot IdentifierZAP70_HUMAN
Bait Gene NameZAP70
Bait OrganismHomo sapiens (Human)
Sequence Position290-296
Critical ResiduesP1; P3; P7
Motif PTM(s)Phosphorylation at Tyr-P3
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Site-directed mutagenesis
Interaction ID21856
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)9407100, 15737992, 10078535
CommentsConsensus sequence for phosphotyrosine recognition by the Cbl TKB domain in Tyrosine-protein kinase ZAP-70 that has been demonstrated to be an important in vivo negative regulatory site for ZAP-70 by Cbl

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)