Instance ID11858
Regular Expression[ND]xY[ST]xxP
Motif InstanceNEYTEGP
Bait Uniprot AccessionO43597
Bait Uniprot IdentifierSPY2_HUMAN
Bait Gene NameSPRY2
Bait OrganismHomo sapiens (Human)
Sequence Position53-59
Critical ResiduesP1; P3; P7
Motif PTM(s)Phosphorylation at Tyr-P3
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21858
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)12815057
CommentsConsensus sequence for phosphotyrosine recognition by the c-Cbl TKB domain in human protein Sprouty homolog 2 and this high affinity interaction is critical for its physiological function in a signal-specific context

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)