Instance ID11861
Regular ExpressionNxY[STEQ]
Motif InstanceNPYE
Bait Uniprot AccessionP43405
Bait Uniprot IdentifierKSYK_HUMAN
Bait Gene NameSYK
Bait OrganismHomo sapiens (Human)
Sequence Position321-324
Critical ResiduesP3
Motif PTM(s)Phosphorylation at Tyr-P3
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Competition binding assay
Interaction ID21861
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15737992, 9857068
CommentsConsensus sequence for phosphotyrosine recognition by the Cbl TKB domain in human Tyrosine-protein kinase SYK that plays a critical role in the recruitment of Cbl to Syk and in Cbl-mediated negative regulation of Syk

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)