Instance ID11863
Regular ExpressionRA[VI]xNQY[ST]
Motif InstanceRAVENQYS
Bait Uniprot AccessionO14492
Bait Uniprot IdentifierSH2B2_HUMAN
Bait Gene NameSH2B2
Bait OrganismHomo sapiens (Human)
Sequence Position623-630
Critical ResiduesP1; P2; P3; P5; P7
Motif PTM(s)Phosphorylation at Tyr-P7
Secondary StructureExtended conformation
Experimental Method(s)X-ray crystallography; Site-directed mutagenesis; ITC
Interaction ID21863
Interacting DomainTKB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)15737992
CommentsNovel Cbl phosphotyrosine recognition motif in SH2B adapter protein 2 (APS) that serves as a binding site for the Cbl TKB domain and allows Cbl ito be recruited to and phosphorylated by the insulin receptor in adipose cells through the adapter protein APS

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)