Instance ID11882
Regular ExpressionYxxM
Motif InstanceYICM
Bait Uniprot AccessionP35570
Bait Uniprot IdentifierIRS1_RAT
Bait Gene NameIrs1
Bait OrganismRattus norvegicus (Rat)
Sequence Position460-463
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay; Competition binding assay
Interaction ID21882
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)1380456
CommentsPhosphorylated YXXM motif 1 (460-463) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)