Instance ID11887
Regular ExpressionYxxM
Motif InstanceYMNM
Bait Uniprot AccessionP35570
Bait Uniprot IdentifierIRS1_RAT
Bait Gene NameIrs1
Bait OrganismRattus norvegicus (Rat)
Sequence Position727-730
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay; Competition binding assay
Interaction ID21887
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)1380456
CommentsPhosphorylated YXXM motif 6 (727-730) in rat Insulin receptor substrate 1 that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)