Instance ID11890
Regular ExpressionYxxM
Motif InstanceYVPM
Bait Uniprot AccessionP05622
Bait Uniprot IdentifierPGFRB_MOUSE
Bait Gene NamePdgfrb
Bait OrganismMus musculus (Mouse)
Sequence Position750-753
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Peptide binding assay; Competition binding assay
Interaction ID21890
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)1380456
CommentsPhosphorylated YXXM motif (750-753) in mouse Platelet-derived growth factor receptor beta that mediates binding to the SH2 domains of rat Phosphatidylinositol 3-kinase regulatory subunit p85-alpha for activation of PtdIns-3-kinase

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)