Instance ID11892
Regular ExpressionYxxM
Motif InstanceYVKM
Bait Uniprot AccessionP16410
Bait Uniprot IdentifierCTLA4_HUMAN
Bait Gene NameCTLA4
Bait OrganismHomo sapiens (Human)
Sequence Position201-204
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Mutational analysis; SPR
Interaction ID21892
Interacting DomainSH2 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11583591
CommentsThe medium chain mu 2 subunit (AP50) of the clathrin-associated adapter protein complex 2 (AP-2) interacts specifically with Cytotoxic T-lymphocyte-associated antigen 4 through the consensus sequence YXXPhi (where X can be any residue and Phi is a large hydrophobic residue)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)