Instance ID11918
Regular ExpressionHLETTF
Motif InstanceHLETTF
Bait Uniprot AccessionP29476
Bait Uniprot IdentifierNOS1_RAT
Bait Gene NameNos1
Bait OrganismRattus norvegicus (Rat)
Sequence Position106-111
Critical ResiduesP4; P6
Motif PTM(s)Unknown
Secondary StructureBeta-hairpin finger
Experimental Method(s)X-ray crystallography; Mutational analysis; Fluorescence-based binding assay; Competition binding assay
Interaction ID21918
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Becker’s muscular dystrophy
Reference(s)11352727, 10221915
CommentsThe PDZ protein interaction domain of rat neuronal nitric oxide synthase (nNOS) that binds to the syntrophin PDZ domain

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)