Instance ID11919
Regular ExpressionHLETTF
Motif InstanceHLETTF
Bait Uniprot AccessionP29476
Bait Uniprot IdentifierNOS1_RAT
Bait Gene NameNos1
Bait OrganismRattus norvegicus (Rat)
Sequence Position106-111
Critical ResiduesP3; P4; P6
Motif PTM(s)Unknown
Secondary StructureBeta-hairpin finger
Experimental Method(s)Mutational analysis; Y2H; Pull down(GST tag)
Interaction ID21919
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Becker’s muscular dystrophy
Reference(s)10488080
Comments"An internal motif adjacent to the rat nNOS (Nos1) PDZ domain, a structured ""pseudo-peptide"" extension of the nNOS PDZ, that interacts with the peptide-binding pocket of rat PSD-95 (Dlg4) PDZ2 domain by a novel PDZ-PDZ interaction"

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)