Instance ID11933
Regular ExpressionNPxY
Motif InstanceNPAY
Bait Uniprot AccessionP24394
Bait Uniprot IdentifierIL4RA_HUMAN
Bait Gene NameIL4R
Bait OrganismHomo sapiens (Human)
Sequence Position494-497
Critical ResiduesUnknown
Motif PTM(s)Phosphorylation at Tyr-P4
Secondary StructureUnknown
Experimental Method(s)NMR
Interaction ID21933
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8599766, 7537849
CommentsThe tyrosine-phosphorylated NPXY motif of Interleukin-4 receptor subunit alpha that mediates its interaction with the PTB domain of Insulin receptor substrate 1 (IRS-1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)