Instance ID11934
Regular ExpressionNPxY
Motif InstanceNPEY
Bait Uniprot AccessionP08069
Bait Uniprot IdentifierIGF1R_HUMAN
Bait Gene NameIGF1R
Bait OrganismHomo sapiens (Human)
Sequence Position977-980
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Tyr-P4
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21934
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7541045, 7537849
CommentsThe tyrosine-phosphorylated NPXY motif of Insulin-like growth factor 1 receptor (IGF1R) that mediates its interaction with the PTB domain of Insulin receptor substrate 1 (IRS-1)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)