Instance ID11936
Regular ExpressionNPxY
Motif InstanceNPEY
Bait Uniprot AccessionP06213
Bait Uniprot IdentifierINSR_HUMAN
Bait Gene NameINSR
Bait OrganismHomo sapiens (Human)
Sequence Position996-999
Critical ResiduesP1; P2; P4
Motif PTM(s)Phosphorylation at Tyr-P4
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis; Y2H
Interaction ID21936
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7537849
CommentsThe tyrosine-phosphorylated NPXY motif of Insulin receptor that mediates its interaction with the PTB domain of SHC-transforming protein 1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)