Instance ID11937
Regular ExpressionNPxY
Motif InstanceNPQY
Bait Uniprot AccessionP04629
Bait Uniprot IdentifierNTRK1_HUMAN
Bait Gene NameNTRK1
Bait OrganismHomo sapiens (Human)
Sequence Position493-496
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Tyr-P4
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Competition binding assay
Interaction ID21937
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)8226808, 7537849
CommentsThe tyrosine-phosphorylated NPXY motif of High affinity nerve growth factor receptor (NTRK1) that mediates its interaction with the PTB domain of SHC-transforming protein 1

© 2014 Bose Institute, Kolkata. All rights reserved

For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)