Instance ID11941
Regular ExpressionNPxY
Motif InstanceNPDY
Bait Uniprot AccessionP00533
Bait Uniprot IdentifierEGFR_HUMAN
Bait Gene NameEGFR
Bait OrganismHomo sapiens (Human)
Sequence Position1169-1172
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Tyr-P4
Secondary StructureUnknown
Experimental Method(s)Mutational analysis; Competition binding assay; Dephosphorylation protection assay
Interaction ID21941
Interacting DomainPTB domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)7542744, 7537849
CommentsThe tyrosine-phosphorylated NPXY motif of Epidermal growth factor receptor that mediates its interaction with the PTB domain of SHC-transforming protein 1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)