Instance ID11947
Regular ExpressionSLLVSWQPPR
Motif InstanceSLLVSWQPPR
Bait Uniprot AccessionP02751
Bait Uniprot IdentifierFINC_HUMAN
Bait Gene NameFN1
Bait OrganismHomo sapiens (Human)
Sequence Position1918-1927
Critical ResiduesP3; P4; P5; P7; P8; P9; P10
Motif PTM(s)Unknown
Secondary StructureBeta sheet
Experimental Method(s)Alanine-scanning mutagenesis; Competition binding assay
Interaction ID21947
Interacting DomainFibronectin-binding motif
Disease Association(s)Mycobacterial infection
Inhibitor(s)Unknown
Reference(s)9446601, 22128161
CommentsThe motif on human Fibronectin (Fn14) required for high affinity binding to the immunodominant antigen (Ag) alpha-Ag (Ag 85 complex B) of Mycobacterium

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)