Instance ID11949
Regular ExpressionKTxxx[WI]
Motif InstanceKTCFEW
Bait Uniprot AccessionO42579
Bait Uniprot IdentifierFZD3_XENLA
Bait Gene Namefzd3
Bait OrganismXenopus laevis (African clawed frog)
Sequence Position501-506
Critical ResiduesP1; P2; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21949
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10990458
CommentsA conserved internal motif sequence in the C-terminal cytoplasmic region of Xenopus membrane-bound receptor Frizzled-3 (Xfz3) that may bind to the conventional peptide binding site in the PDZ domain of the mouse cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)