Instance ID11952
Regular ExpressionKTxxx[WI]
Motif InstanceKTLQSW
Bait Uniprot AccessionQ8AVJ9
Bait Uniprot IdentifierFZD7B_XENLA
Bait Gene Namefzd7-b
Bait OrganismXenopus laevis (African clawed frog)
Sequence Position526-531
Critical ResiduesP1; P2; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; NMR
Interaction ID21952
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10990458, 14636582
CommentsA conserved internal motif sequence in the C-terminal cytoplasmic region of Xenopus membrane-bound receptor Frizzled-7-B (Xfz7-B) that binds to the conventional peptide binding site in the PDZ domain of the mouse cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)