Instance ID11953
Regular ExpressionKTxxx[WI]
Motif InstanceKTMVSW
Bait Uniprot AccessionP18537
Bait Uniprot IdentifierFRIZ_DROME
Bait Gene Namefz
Bait OrganismDrosophila melanogaster (Fruit fly)
Sequence Position556-561
Critical ResiduesP1; P2; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21953
Interacting DomainPDZ domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)10990458, 19234454
CommentsA conserved internal motif sequence in the C-terminal cytoplasmic region of Drosophila membrane-bound receptor Frizzled-1 (dFz1) that may bind to the conventional peptide binding site in the PDZ domain of the cytoplasmic protein Dishevelled (Dvl) suggesting a role of this conserved motif in the modulation of Wnt signalling

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)