Instance ID11955
Regular ExpressionPxLPx[IL]
Motif InstancePSLPNI
Bait Uniprot AccessionP56524
Bait Uniprot IdentifierHDAC4_HUMAN
Bait Gene NameHDAC4
Bait OrganismHomo sapiens (Human)
Sequence Position349-354
Critical ResiduesP1; P3; P4; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Peptide array binding assay; Mutational analysis; ITC
Interaction ID21955
Interacting DomainAnkyrin repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)22649097, 15964851
CommentsThe PxLPxI/L motif of human Histone deacetylase 4 recognized by Ankyrin repeat family A protein 2 (ANKRA2) for signal-dependent binding to the ankyrin repeat domain

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)