Instance ID11972
Regular ExpressionNxI
Motif InstanceNAI
Bait Uniprot AccessionO94907
Bait Uniprot IdentifierDKK1_HUMAN
Bait Gene NameDKK1
Bait OrganismHomo sapiens (Human)
Sequence Position40-42
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Mutational analysis; Competition binding assay; BLI; ELISA
Interaction ID21972
Interacting DomainE1 domain
Disease Association(s)Cancer; Alzheimer's disease; Bone disease
Inhibitor(s)Unknown
Reference(s)21944579
CommentsThe NxI peptide motif in the Wnt pathway inhibitor Dickkopf-1 (DKK1) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 thereby inhibiting LRP6 interaction with Wnt

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)