Instance ID11973
Regular ExpressionNxI
Motif InstanceNSI
Bait Uniprot AccessionQ9UBU2
Bait Uniprot IdentifierDKK2_HUMAN
Bait Gene NameDKK2
Bait OrganismHomo sapiens (Human)
Sequence Position36-38
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction; BLI
Interaction ID21973
Interacting DomainE1 domain
Disease Association(s)Cancer; Alzheimer's disease; Bone disease
Inhibitor(s)Unknown
Reference(s)21944579
CommentsThe NxI peptide motif in the Wnt pathway inhibitor Dickkopf-2 (DKK2) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 thereby inhibiting LRP6 interaction with Wnt

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)