Instance ID11974
Regular ExpressionNxI
Motif InstanceNAI
Bait Uniprot AccessionQ9BQB4
Bait Uniprot IdentifierSOST_HUMAN
Bait Gene NameSOST
Bait OrganismHomo sapiens (Human)
Sequence Position117-119
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)X-ray crystallography; Mutational analysis; Competition binding assay; BLI; ELISA
Interaction ID21974
Interacting DomainE1 domain
Disease Association(s)Bone dysplasia
Inhibitor(s)Unknown
Reference(s)21944579
CommentsThe NxI peptide motif in the Wnt pathway inhibitor Sclerostin (SOST) that is important for binding to the E1 propeller domain of Wnt coreceptor LRP6 and for inhibitory function

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)