Instance ID11979
Regular Expression[YF]xLxP
Motif InstanceYRLSP
Bait Uniprot AccessionQ8NEM0
Bait Uniprot IdentifierMCPH1_HUMAN
Bait Gene NameMCPH1
Bait OrganismHomo sapiens (Human)
Sequence Position330-334
Critical ResiduesP1; P3
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutational analysis
Interaction ID21979
Interacting DomainTRFH domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)19287395
CommentsThe telomeric repeat binding factor (TRF) homology (TRFH) domain of human Telomeric repeat-binding factor 2 (TERF2/TRF2) recognizes and directly interacts with the [Y/F]XL motif in human Microcephalin (MCPH1) and regulates telomere maintenance

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)