Instance ID11985
Regular ExpressionPxLx[IL]T
Motif InstancePSLPIT
Bait Uniprot AccessionP0C215
Bait Uniprot IdentifierP12I_HTL1A
Bait Gene NameNot Available
Bait OrganismHuman T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
Sequence Position70-75
Critical ResiduesP1; P3; P5; P6
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Site-directed mutagenesis
Interaction ID21985
Interacting DomainCalcineurin-like phosphoesterase domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)12601010
CommentsThe conserved calcineurin-binding motif in human T lymphotropic virus type 1 Accessory protein p12I that mediates its interaction with human Calmodulin-dependent calcineurin A subunit alpha isoform (PPP3CA) and modulates NFAT activation to promote early virus infection of T lymphocytes, providing a novel mechanism for retrovirus-mediated cell activation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)