Instance ID11987
Regular ExpressionTPxx[SE]
Motif InstanceTPSPE
Bait Uniprot AccessionQ01705
Bait Uniprot IdentifierNOTC1_MOUSE
Bait Gene NameNotch1
Bait OrganismMus musculus (Mouse)
Sequence Position2487-2491
Critical ResiduesUnknown
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Sequence based prediction
Interaction ID21987
Interacting DomainWD40 repeat domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)11461910
CommentsThe mouse Neurogenic locus notch homolog protein 1 (Notch1) intracellular domain is ubiquitinated and negatively regulated by the mouse F-box/WD repeat-containing protein 7 (Fbxw7) through a phosphodegron motif recognized by WD40 beta propeller

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)