Instance ID11988
Regular Expression(Y)xNx
Motif InstanceYDNY
Bait Uniprot AccessionP09619
Bait Uniprot IdentifierPGFRB_HUMAN
Bait Gene NamePDGFRB
Bait OrganismHomo sapiens (Human)
Sequence Position775-778
Critical ResiduesP1
Motif PTM(s)Phosphorylation at Tyr-P1
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID21988
Interacting DomainSH2 domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)8940081
CommentsThe SH2 domain of Human Epidermal growth factor receptor GRB-7 can directly bind to the autophosphorylated PDGF beta-receptor (PDGFRB) through Tyr-775

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)