Instance ID11994
Regular ExpressionPPxY
Motif InstancePPRY
Bait Uniprot AccessionP08363
Bait Uniprot IdentifierVP8_BTV10
Bait Gene NameS10
Bait OrganismBluetongue virus 10 (isolate USA) (BTV 10)
Sequence Position36-39
Critical ResiduesP1; P2
Motif PTM(s)Unknown
Secondary StructureUnknown
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID21994
Interacting DomainWW domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)16352570
CommentsNon-structural protein NS3 (S10) of Bluetongue virus (BTV) harbors a PPXY late-domain motif that allows NS3 to bind Human E3 ubiquitin-protein ligase Itchy homolog (ITCH)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)