Instance ID11997
Regular ExpressionDYR
Motif InstanceDYR
Bait Uniprot AccessionP08581
Bait Uniprot IdentifierMET_HUMAN
Bait Gene NameMET
Bait OrganismHomo sapiens (Human)
Sequence Position1002-1004
Critical ResiduesP1; P2; P3
Motif PTM(s)Phosphorylation at Tyr-P2
Secondary StructureUnknown
Experimental Method(s)Alanine-scanning mutagenesis; Co-IP; Far Western blotting; Competition binding
Interaction ID21997
Interacting DomainTKB Domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)15123609
CommentsThe ubiquitination of human Proto-oncogene c-Met by human Proto-oncogene c-Cbl requires the direct interaction of the c-Cbl Tyrosine Kinase binding (TKB) domain with conserved DpY(1003)R motif in the Met juxtamembrane domain leading to suppression of oncogenic activation

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)