Instance ID11998
Regular ExpressionDYR
Motif InstanceDYR
Bait Uniprot AccessionP08581
Bait Uniprot IdentifierMET_HUMAN
Bait Gene NameMET
Bait OrganismHomo sapiens (Human)
Sequence Position1002-1004
Critical ResiduesP1; P2; P3
Motif PTM(s)Phosphorylation at Tyr-P2
Secondary StructureUnknown
Experimental Method(s)Alanine-scanning mutagenesis; Pull down(GST tag)
Interaction ID21998
Interacting DomainTKB Domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)15123609
CommentsThe TKB domain of human E3 ubiquitin-protein ligase CBL-B binds to human Hepatocyte growth factor receptor (MET) via the conserved DpY(1003)R motif in the MET juxtamembrane domain

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)