Instance ID11999
Regular ExpressionETGE
Motif InstanceETGE
Bait Uniprot AccessionQ60795
Bait Uniprot IdentifierNF2L2_MOUSE
Bait Gene NameNfe2l2
Bait OrganismMus musculus (Mouse)
Sequence Position79-82
Critical ResiduesP1; P4
Motif PTM(s)Unknown
Secondary StructureBeta turn
Experimental Method(s)Mutation analysis; Co-IP; X-ray crystallography; ITC
Interaction ID21999
Interacting DomainDGR domain
Disease Association(s)Cancer
Inhibitor(s)Unknown
Reference(s)16507366
CommentsThe ETGE motif within the N-terminal Neh2 domain of mouse Nrf2, a basic region-leucine zipper (bZIP) transcription factor, binds the DGR domain in the beta propeller of mouse Keap1, which is essential to suppress Nrf2 activity

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)