Instance ID12002
Regular Expression[RK]xK[ST]Cxxx$
Motif InstanceKAKSCTVM
Bait Uniprot AccessionP61587
Bait Uniprot IdentifierRND3_HUMAN
Bait Gene NameRND3
Bait OrganismHomo sapiens (Human)
Sequence Position237-244
Critical ResiduesP4
Motif PTM(s)Phosphorylation at Ser-P4; Farnesylation at Cys-P5
Secondary StructureUnknown
Experimental Method(s)Peptide Pull-Down Assay; Co-IP; Pull down(GST tag)
Interaction ID22002
Interacting Domain14-3-3 domain
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)23622247
CommentsC-terminal hybrid III/IV 14-3-3-binding motif in human Rho family GTPase 3 (RND3) that interacts with human 14-3-3 protein beta on being phosphorylated at Ser-240 by ROCK1

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)