Instance ID12018
Regular Expressionxxx[ST]x[ACVILF]$
Motif InstanceQRYSDF
Bait Uniprot AccessionQ9AJU4
Bait Uniprot IdentifierQ9AJU4_SHIFL
Bait Gene NameospE1
Bait OrganismShigella flexneri
Sequence Position86-88
Critical ResiduesP4; P5; P6
Motif PTM(s)Unknown
Secondary StructureDisordered
Experimental Method(s)Mutation analysis; Pull down(GST tag)
Interaction ID22018
Interacting DomainPDZ domain
Disease Association(s)Shigellosis
Inhibitor(s)Unknown
Reference(s)25124035
CommentsC-terminal class 1 PDZ-binding motif in the effector protein OspE1 of Shigella flexneri serotype 2a strain 2457T that mediates its interaction with human PDZ and LIM domain protein 7 (PDLIM7/ENIGMA), leading to activation of isoforms of protein kinase C (PKC)

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)