Instance ID12023
Regular ExpressionHPD
Motif InstanceHPD
Bait Uniprot AccessionP0A6L9
Bait Uniprot IdentifierHSCB_ECOLI
Bait Gene NamehscB
Bait OrganismEscherichia coli (strain K12)
Sequence Position32-34
Critical ResiduesP1; P2; P3
Motif PTM(s)Unknown
Secondary StructureAlpha helix
Experimental Method(s)Mutation analysis; NMR
Interaction ID22023
Interacting DomainUnknown
Disease Association(s)Unknown
Inhibitor(s)Unknown
Reference(s)25080945
CommentsATP-/ADP-dependent interactions between Escherichia coli HscA and HscB, the specialized Hsp70/Hsp40 molecular chaperones that mediate iron-sulfur cluster transfer, involve the HPD motif in the J-domain of HscB that directly interacts with ATP-bound HscA

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For queries, suggestions and submission of novel motifs please contact Dr. Sudipto Saha (ssaha4@jcbose.ac.in)